To modify and replace the Spine shortcut keys, you need to edit the hotkeys.txt file located in your user home folder. The location of this file varies depending on your operating system:

• Windows: <user home folder>\Spine\hotkeys.txt
• Mac: <user home folder>/Library/Application Support/Spine/hotkeys.txt
• Linux: <user home folder>/.spine/hotkeys.txt

Once you have located the hotkeys.txt file, you can open it with a text editor and modify the hotkeys as needed. Use Ctrl-F (Windows, Linux) or Cmd-F (Mac) to find specific hotkeys you want to change. After making your changes, save the file and restart Spine for the changes to take effect.