skaen Yes, resizing the prefabs would work, but in the case of spine-unity, there is a more convenient way to adjust the size of your skeleton. If you change the Scale property of the SkeletonDataAsset, you can adjust the scale when it is instantiated so that the skeleton can be displayed at the correct size if the GameObject's scale is X:1 Y:1 Z:1.
The convenience of spine-unity is that you can change the Default SkeletonData Scale in the Spine section of Unity's Preferences window. This ensures that when your skeleton data is imported into Unity and the SkeletonDataAsset is created, this scale value is automatically applied.
For example, the default value for the SkeletonDataAsset Scale property is 0.01, but if you want to display the skeleton as if you set the root bone's X/Y scale to 0.5, set it to 0.005 and it should be the size you expect.